Recent Applications of Pillararene-Inspired Water-Soluble Hosts
Yujie Zhu1, Ya Gao1, Julius Rebek1
1Center for Supramolecular Chemistry & Catalysis and Department of Chemistry, Institution College of Science, Shanghai University, Shanghai, 200444, China.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|January 2, 2025
Summary
This review highlights water-soluble pillararene derivatives, including leaning towerarenes and helicarenes. These macrocycles show promise in drug delivery, nanoparticle fabrication, and biomedicine, advancing supramolecular chemistry applications.
Area of Science:
- Supramolecular Chemistry
- Macrocyclic Chemistry
- Materials Science
Background:
- Pillararenes are unique macrocycles utilized in supramolecular chemistry.
- Recent advancements have focused on developing water-soluble pillararene derivatives.
- These macrocycles have diverse applications in host-guest chemistry and biomimetics.
Purpose of the Study:
- To review progress in water-soluble pillararene derivatives.
- To highlight their applications in various scientific and medical fields.
- To guide future research in synthetic macrocyclic chemistry.
Main Methods:
- Synthesis of various water-soluble pillararene derivatives.
- Exploration of host-guest complexation properties.
- Investigation of applications in targeted delivery and materials science.
Main Results:
- Detailed progress on water-soluble pillararenes: leaning towerarenes, extended-pillararenes, biphenarenes, helicarenes, and octopusarenes.
- Demonstrated applications in targeted drug delivery and selective guest uptake/release.
- Successful use in fabricating nanoparticles and in various biomedical applications, including biofilm disruption and antidotes.
Conclusions:
- Water-soluble pillararene derivatives offer significant potential for supramolecular chemistry.
- These macrocycles are versatile for applications ranging from drug delivery to environmental remediation.
- Further research into these systems will drive practical applications in diverse areas.
