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Updated: Jun 4, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Published on: December 11, 2016

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Bioinformatics Based Drug Repurposing Approach for Breast and Gynecological Cancers: RECQL4/FAM13C Genes Address

Gizem Ayna Duran1

  • 1Department of Biomedical Engineering, Faculty of Engineering, İzmir University of Economics, İzmir, Turkey.

European Journal of Breast Health
|January 2, 2025
PubMed
Abstract

Insights

This study identifies common genes and drug targets in breast and gynecological cancers. It suggests repurposing existing drugs for these cancers, offering new treatment avenues.

Area of Science:

  • Oncology
  • Genomics
  • Pharmacology

Background:

  • Breast and gynecological cancers have high prevalence and can occur as secondary malignancies.
  • Identifying common molecular targets is crucial for understanding and treating these related cancers.

Purpose of the Study:

  • To identify commonly expressed genes in breast and gynecological cancers.
  • To pinpoint common hub genes and potential drug components for these cancers.
  • To explore drug repurposing opportunities for breast and gynecological cancer treatment.

Main Methods:

  • Utilized gene expression data from the Gene Expression Omnibus database.
  • Employed R LIMMA package for differential gene expression analysis.
  • Identified hub genes using Cytoscape and cytoHubba, and predicted drug-target relationships with ShinyGo's Drug.MATADOR tool.

Main Results:

  • Identified RecQ Like Helicase 4 and Family with Sequence Similarity 13 Member C as commonly expressed genes.
  • Determined gene-drug interactions: NBN-Hydroxyurea, EP300-Acetylcarnitine, and MAPK14-Salicylate/Dibutyryl cyclic AMP.
  • KEGG pathway analysis highlighted cancer-related pathways involving hub genes.

Conclusions:

  • The identified drug-gene interactions involve drugs not currently standard for cancer treatment.
  • This research supports a drug repurposing strategy for breast and gynecological cancers.
  • Offers potential for novel therapeutic approaches by targeting identified hub genes.
Keywords:
Breast cancerDEGsRECQL4/FAM13Cdrug repurposinggynaecological cancershub genes

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