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Related Experiment Video

Updated: May 7, 2025

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

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Rescue stenting after failed mechanical thrombectomy: The RES-CAT study.

Roger Collet-Vidiella1, Pol Camps-Renom1, Ana Núñez-Guillén2

  • 1Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Barcelona, Spain.

European Stroke Journal
|January 2, 2025
PubMed

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Contemporary achievement of guideline recommendations for blood pressure management after stroke in the CONVINCE trial.

European stroke journal·2026
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Blood-Brain Barrier Disruption Before Interhospital Transfer for Thrombectomy and Clinical Outcome.

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Specific HLA-DRB1 Alleles Associate With Anti-Caspr1 and Anti-CNTN1 Autoantibodies in Autoimmune Nodopathies.

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Personalized Blood Pressure Targeting After Endovascular Therapy for Acute Ischemic Stroke: A Randomized Clinical Trial.

JAMA neurology·2026
Summary

Rescue stenting (RS) after failed mechanical thrombectomy (MT) for large-vessel occlusion (LVO) stroke may improve good and excellent outcomes. This intervention did not increase long-term risks like mortality or stroke recurrence.

Area of Science:

  • Neurology
  • Interventional Neuroradiology
  • Stroke Medicine

Background:

  • Mechanical thrombectomy (MT) is a primary treatment for large-vessel occlusion (LVO) stroke.
  • The role of intracranial rescue stenting (RS) after failed MT remains unclear.
  • Evaluating RS efficacy in anterior circulation LVO stroke is crucial.

Purpose of the Study:

  • To assess the clinical outcomes of rescue stenting (RS) in patients with anterior circulation LVO stroke following unsuccessful mechanical thrombectomy (MT).
  • To compare functional status, complication rates, and mortality between patients who received RS and those who did not.

Main Methods:

  • Retrospective analysis of a prospective, population-based registry (Stroke Code Registry of Catalonia, 2016-2022).
  • Included 601 patients with anterior circulation LVO stroke; 69 underwent RS after failed MT.
Keywords:
Thrombectomyendovascular techniqueintracranial atherosclerosisintracranial stenosisreperfusionrescue stentingstent

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  • Used inverse probability of treatment weighting (IPTW) to adjust for confounders and analyzed 90-day functional outcomes (modified Rankin Scale), complications, and mortality.

    • Main Results:

    • Rescue stenting (RS) did not significantly alter the overall 90-day functional status shift (acOR 1.06).
    • However, RS was associated with significantly higher rates of good (18.8% vs 11.7%) and excellent (17.4% vs 5.7%) functional outcomes.
    • No significant differences were observed in symptomatic intracranial hemorrhage, 90-day mortality, or stroke recurrence between groups.

    Conclusions:

    • Rescue stenting (RS) may enhance good and excellent functional outcomes in anterior LVO stroke patients with failed MT.
    • RS appears safe, not increasing long-term risks such as hemorrhage, mortality, or recurrence.
    • Further randomized controlled trials are needed to validate these findings.