Evaluating Feasibility of an Exercise Intervention Including Physical Assessment During the First 6 Months of Cancer...

The aim was to assess the feasibility of a randomized controlled exercise intervention, including physical assessments, in children and adolescents during the first 6 months of cancer treatment.

A sample of children and adolescents (n = 84, 6‒17.9 years) from an ongoing trial (INTERACT: NCT04706676) was randomly assigned to an integrative neuromuscular training (INT) intervention or active control intervention during treatment. The following inter-related feasibility domains were assessed: availability, acceptance, and attrition. Further, we assessed adherence to INT and physical assessments. Adverse events related to exercise and physical assessments were also reported.

We found feasible rates within the availability and attrition domains. While the INT group demonstrated feasible group-level adherence rates, individual adherence to prescribed intervention demands was suboptimal. Physical assessments after 6 months of cancer treatment showed feasible rates.

This study offers insights into the feasibility of an early-initiated INT intervention designed for children and adolescents undergoing cancer treatment. To ensure an optimal frequency of exercise in future studies, a flexible approach to hospital-based INT and a structured strategy for home-based exercise should be considered. Future trials should prioritize outcomes to minimize the length and timing of assessment.