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Updated: Jun 4, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Polyfluoroalkanoic Acids as Fluoroalkylating Reagents: Strategy for Direct Access to Rf-Embedded Amides
Lalit Mohan Kabadwal1, Shuvojit Haldar1, Atanu Bera1
1Laboratory of Catalysis and Organic Synthesis, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India.
Abstract:
Herein, we have reported the application of bench stable perfluoroalkanoic acids as fluoro-alkylating reagents in combination with DIB and primary amides for sequential one-pot transformation to Rf-embedded functionalized amides under metal-free conditions. The protocol is tolerant to a range of sensitive functional groups (>33 examples and up to 90% yield), and perfluoro acids. Preliminary mechanistic studies, control experiments, in situ 19F-NMR analyses, and the synthesis of intermediate species were performed to understand the reaction pathways.
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