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Updated: Jun 4, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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G9a/GLP Modulators: Inhibitors to Degraders

Anirban Mukherjee1, Takayoshi Suzuki1

  • 1SANKEN, Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan.

Journal of Medicinal Chemistry
|January 2, 2025
PubMed
Summary

G9a, a key epigenetic enzyme, regulates DNA and gene expression. Inhibiting G9a shows promise for treating cancers and Alzheimer's disease by targeting aberrant methylation patterns.

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