Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Muscle Stimulation Frequency01:22

Muscle Stimulation Frequency

2.0K
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

tACS of the Cerebellum and the Motor Cortex Entrains the Spiking Activity of the Cells in Motor Thalamus in a Frequency Dependent Manner.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2025
Same author

Striatal signaling tracks naturalistic short-term fluctuations in hunger-satiety.

bioRxiv : the preprint server for biology·2025
Same author

Entrainment of Cerebellar Nuclear Cells via AC Stimulation of the Cerebellar Cortex.

International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering·2025
Same author

Modulation of Cerebellar Nuclear Activity by Transcranial AC Stimulation in Awake Rats.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Transsynaptic modulation of cerebellar nuclear cells: theta AC-burst stimulation.

Journal of neural engineering·2024
Same author

Cerebellar transcranial AC stimulation produces a frequency-dependent bimodal cerebellar output pattern.

Research square·2024

Related Experiment Video

Updated: Jun 4, 2025

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum
11:47

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum

Published on: February 15, 2015

28.5K

Cerebellar Transcranial AC Stimulation Produces a Frequency-Dependent Bimodal Cerebellar Output Pattern.

Devry Mourra1, Angela M Cavalieri1, Madison M Casey1

  • 1Department of Neuroscience and Physiology, Grossman School of Medicine, NYU Neuroscience Institute, New York University, New York, NY, 10016, USA.

Cerebellum (London, England)
|January 2, 2025
PubMed
Summary

Cerebellar transcranial alternating current stimulation (ctACS) modulates neural activity in rats. Electrode placement influences ctACS effects, suggesting targeted cerebellar therapies for neurological and psychiatric disorders.

Keywords:
Alternating current stimulationCerebellar nucleiNeuromodulation of cerebellumPurkinje cellTranscranial electrical stimulation

More Related Videos

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation
11:11

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

Published on: September 23, 2017

9.0K
Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging
10:25

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging

Published on: June 5, 2017

13.9K

Related Experiment Videos

Last Updated: Jun 4, 2025

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum
11:47

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum

Published on: February 15, 2015

28.5K
Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation
11:11

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

Published on: September 23, 2017

9.0K
Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging
10:25

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging

Published on: June 5, 2017

13.9K

Area of Science:

  • Neuroscience
  • Neurostimulation
  • Cerebellar Function

Background:

  • Cerebellar transcranial alternating current stimulation (ctACS) shows promise for treating neurological and psychiatric disorders.
  • Understanding ctACS effects on cerebellar output at cellular levels is crucial for its clinical application.
  • Previous research demonstrated frequency-dependent modulation of Purkinje cells (PCs) and cerebellar nuclear (CN) cells by direct cerebellar surface stimulation.

Purpose of the Study:

  • To investigate the effects of ctACS applied to the skull surface on cerebellar PC and CN activity in rats.
  • To determine the frequency-dependence of ctACS on cerebellar neural output.
  • To explore how electrode placement influences ctACS-induced modulation of cerebellar activity.

Main Methods:

  • AC stimulation was applied to the external skull surface overlying crus 1 in anesthetized rats.
  • PC and CN cell activity was recorded and analyzed for frequency-dependent modulation.
  • Comparisons were made between ipsilateral and contralateral stimulus electrode placements relative to the recording site.

Main Results:

  • ctACS induced frequency-dependent modulation of both PC and CN cell activity from 0.5 to 80 Hz.
  • PCs typically exhibited unimodal responses, while CN cells showed a transition to bimodal patterns with increasing frequency.
  • CN cell modulation patterns suggested synaptic input from PCs.
  • Stimulus electrode location significantly affected the strength and pattern of neural entrainment.

Conclusions:

  • Transcranial stimulation of the cerebellar cortex can modulate cerebellar output.
  • The findings support the potential of ctACS as a non-invasive neuromodulation technique for psychiatric and neurological disorders.
  • ctACS electrode placement can be optimized to target specific cerebellar output pathways.