Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

375
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
375
Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

725
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
725
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

779
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
779
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

96
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
96
Specialized Care Centers and Settings-II01:30

Specialized Care Centers and Settings-II

700
Rural Health Centers
Rural health centers are specialized care facilities in remote locations with very few medical personnel. The primary care providers who run the centers are mostly Registered Nurse Practitioners. Here, emergency treatment is provided to critically ill or injured patients before they are transferred to the closest hospital. Fortunately, due to advancement in technology, many rural healthcare facilities and professionals have easy access to diagnostic and treatment...
700
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

409
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
409

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preparedness of the Emergency Medical Services Educational System: Pandemic Barriers and Adaptations.

Journal of the American College of Emergency Physicians open·2026
Same author

Identifying Themes for EMS Continued Competency That Are Acceptable and Improve Patient Care.

Prehospital emergency care·2026
Same author

First Responders Have Lower COVID-19 Vaccination Rates Than Other Healthcare Providers.

Journal of the American College of Emergency Physicians open·2026
Same author

Agency-Level Turnover Rates of Emergency Medical Service Clinicians and Their Characteristics.

Journal of the American College of Emergency Physicians open·2026
Same author

Resuscitation From Out-of-Hospital Cardiac Arrest: When Is EtCO<sub>2</sub> Reliably Associated With ROSC?

Circulation·2026
Same author

Preparing Emergency Medicine Residents for the Certifying Exam: A Pilot Study of a Longitudinal Simulation-Based Assessment Program.

AEM education and training·2026

Related Experiment Video

Updated: Jun 4, 2025

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

718

Pediatric Emergency Medical Services Activations Involving Naloxone Administration.

Christopher E Gaw1,2, Christopher B Gage3,4, Jonathan R Powell3,4

  • 1Division of Emergency Medicine, Nationwide Children's Hospital, Columbus, Ohio.

Prehospital Emergency Care
|January 2, 2025
PubMed
Summary

Emergency medical services (EMS) administered naloxone to over 6,000 children in 2022. Over half improved clinically after the first dose, showing prehospital naloxone is safe and effective for pediatric opioid poisonings.

More Related Videos

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

30.4K
A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn
11:27

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn

Published on: April 7, 2023

6.1K

Related Experiment Videos

Last Updated: Jun 4, 2025

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

718
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

30.4K
A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn
11:27

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn

Published on: April 7, 2023

6.1K

Area of Science:

  • Emergency Medicine
  • Pediatric Toxicology
  • Public Health

Background:

  • Pediatric opioid poisonings are rising, necessitating effective prehospital interventions.
  • Emergency medical services (EMS) are crucial in responding to and treating pediatric opioid poisonings.
  • Current data on prehospital naloxone use in children is limited.

Purpose of the Study:

  • To characterize the epidemiology of naloxone administrations by EMS for pediatric patients in the U.S.
  • To describe demographic and clinical factors associated with prehospital naloxone use in children.

Main Methods:

  • A cross-sectional study using the National Emergency Medical Services Information System (NEMSIS) database.
  • Analysis of 6,215 emergency activations in 2022 involving naloxone administration to children aged 1 day to 17 years.
  • Examination of demographic data, dispatch complaints, and clinical outcomes post-naloxone administration.

Main Results:

  • Naloxone was administered in 6,215 pediatric activations in 2022, with highest prevalence in adolescents (13-17 years).
  • Over half (54.1%) of activations showed clinical improvement after the first naloxone dose; worsening occurred in only 0.2%.
  • Dispatch complaints of overdose/poisoning were documented in 28.9% of activations, more common in adolescents.

Conclusions:

  • Prehospital naloxone use in pediatric activations is generally safe and effective, with significant clinical improvement observed.
  • A high index of suspicion for opioid poisoning is vital in pediatric emergencies, even without explicit overdose dispatch.
  • Further research using linked data can enhance recognition and management of pediatric opioid poisonings.