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Updated: Jun 4, 2025

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Targeting the tumor microenvironment with mesenchymal stem cells based delivery approach for efficient delivery of

Yang Yu1, Ying Tao2, Jingru Ma3

  • 1Department of Emergency and Critical Care, the Second Hospital of Jilin University, Changchun 130000, China.

Biochemical Pharmacology
|January 2, 2025
PubMed

Insights

Mesenchymal stem cells (MSCs) offer targeted cancer drug delivery. Combining MSCs with nanoparticles, especially cell membrane-coated ones, significantly boosts anti-tumor activity and therapeutic potential.

Area of Science:

  • Biomedical Engineering
  • Oncology
  • Regenerative Medicine

Background:

  • Targeted drug delivery to cancer cells remains a significant therapeutic challenge.
  • Mesenchymal stem cells (MSCs) exhibit natural tumor-homing capabilities, making them ideal for targeted delivery.
  • Preclinical and clinical studies show promise for MSC-based anti-cancer therapies.

Purpose of the Study:

  • To systematically review MSCs for cancer drug delivery.
  • To explore MSC sources, tumor homing, and drug loading/release mechanisms.
  • To discuss advanced strategies, including MSC membrane-coated nanoparticles, for enhanced efficacy.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of MSC tumor microenvironment interactions and homing mechanisms.
  • Investigation of drug loading, release kinetics, and nanoparticle integration.

Main Results:

  • MSCs loaded with anti-cancer agents demonstrate significant anti-tumor activity.
  • Integration with nanoparticles, particularly MSC membrane-coated NPs, enhances therapeutic potential.
  • Various strategies exist for optimizing MSC-based drug delivery systems.

Conclusions:

  • MSCs are effective drug carriers for targeted cancer therapy.
  • MSC membrane-coated nanoparticles represent a cutting-edge advancement.
  • Further research can optimize MSC-based approaches for future cancer treatments.
Keywords:
CancerMesenchymal Stem CellsTargeted Drug deliveryTumor Microenvironment

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