Mechanical Circulatory Support for Septic Shock in Children and Adults: Different But Similar

Although extracorporeal membrane oxygenation (ECMO) for circulatory support in patients with severe septic shock commenced in newborn infants and children in the late 1980s, ECMO has remained a controversial treatment for adults with refractory septic shock (RSS). This is fundamentally because of differences in the predominant hemodynamic response to sepsis. In newborn infants and very young children ventricular failure, low cardiac output syndrome (LCOS) is the major hemodynamic response whereas adolescents and adults mainly have vasoplegic shock. ECMO is a very effective treatment for cardiogenic shock even shock caused by sepsis, with a survival that has varied from 40% to 70%; vasoplegic shock, however, requires vasopressors rather than ECMO, and hence survival of these patients with ECMO was poor (< 20%). However, since the early 2000s, sepsis- induced cardiomyopathy (SCM) with ventricular failure (identical to LCOS in children) has been increasingly described in adults, and the occurrence of cardiogenic shock caused by septic shock is treatable with ECMO. In the last 6 years, increasing publications of series of adults with RSS and cardiogenic shock receiving ECMO and ∼70+% surviving has led to increased use of VA ECMO for RSS.