Multi-drug sequential release systems: Construction and application for synergistic tumor treatment

Area of Science:

• Biomedical Engineering
• Materials Science
• Oncology

Background:

• Therapeutic efficacy in tumor treatment is significantly influenced by the sequence and timing of drug administration.
• Multi-drug sequential release systems (MDSRS) offer a strategy for controlled, simultaneous, or sequential delivery of multiple therapeutic agents.
• Recent advancements focus on synergistic cancer therapy through precisely timed drug release.

Purpose of the Study:

• To review the characteristics and design principles of Multi-drug sequential release systems (MDSRS).
• To summarize carrier structures utilized in MDSRS for cancer treatment.
• To highlight the application of MDSRS in modulating the tumor microenvironment (TME) and enhancing therapeutic outcomes.

Main Methods:

• Review of existing literature on Multi-drug sequential release systems (MDSRS).
• Analysis of various carrier structures (e.g., core-shell, layer-by-layer, Janus, hydrogels).
• Examination of specific examples demonstrating MDSRS application in cancer therapy and TME modulation.

Main Results:

• MDSRS exhibit diverse characteristics and design principles tailored for controlled drug release.
• Various carrier architectures facilitate the sequential delivery of multiple drugs.
• MDSRS show promise in remodeling the tumor microenvironment (TME) and improving cancer treatment efficacy through multiple mechanisms.

Conclusions:

• The sequence and timing of drug delivery are critical for effective cancer therapy.
• MDSRS represent a valuable platform for synergistic cancer treatment by enabling precise control over drug release.
• Further research into MDSRS limitations and challenges can guide future pharmaceutical development for improved cancer care.