Related Experiment Video

Updated: Jun 24, 2026

Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion
07:43

Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion

Published on: February 22, 2013

14.9K

Hemodynamic evaluation of symptomatic and asymptomatic intracranial atherosclerotic stenosis using cerebral

Jiayan Li1, Lijun Wang1, Yongxin Zhang1

  • 1Neurovascular Center, Changhai Hospital, Shanghai, China.

Journal of Neurointerventional Surgery
|January 2, 2025
PubMed

Insights

Fractional flow (FF) assessed via non-invasive intracranial angiography (Angio-FF) can differentiate symptomatic and asymptomatic intracranial atherosclerotic stenosis (ICAS). Lower Angio-FF values indicate a higher risk of ischemic events in ICAS patients.

Area of Science:

  • Neurology
  • Cardiovascular Research
  • Medical Imaging

Background:

  • Intracranial atherosclerotic stenosis (ICAS) treatment decisions based solely on stenosis degree may be inadequate.
  • Novel non-invasive fractional flow (FF) calculation technique using intracranial angiography (Angio-FF) developed to assess ICAS hemodynamics.
  • Need for improved risk stratification in ICAS patients.

Purpose of the Study:

  • Investigate the difference in Angio-FF between symptomatic and asymptomatic ICAS patients.
  • Determine the optimal Angio-FF threshold for differentiating symptomatic from asymptomatic ICAS.
  • Evaluate Angio-FF's potential in predicting clinical symptoms and ischemic events.

Main Methods:

  • Recruited 124 patients with severe ICAS undergoing cerebral angiography.
  • Divided patients into symptomatic (n=78) and asymptomatic (n=46) groups based on symptom onset.
  • Collected and compared Angio-FF values; performed ROC analysis to assess discriminative ability.

Main Results:

  • Symptomatic ICAS group showed significantly lower Angio-FF (0.75) compared to asymptomatic group (0.85).
  • Optimal Angio-FF cut-off value for distinguishing symptomatic from asymptomatic ICAS was 0.785.
  • The cut-off achieved 71.74% sensitivity and 57.69% specificity.

Conclusions:

  • Angio-FF <0.7853 may indicate increased susceptibility to intracranial ischemic events.
  • Angio-FF of 0.7853 serves as a potential threshold for identifying clinical symptoms in ICAS patients.
  • Angio-FF offers a valuable non-invasive hemodynamic assessment for ICAS risk stratification.
Abstract

Keywords:
AngiographyAtherosclerosisBlood FlowStenosis

More Related Videos

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

2.9K
Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound10:41

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound

Published on: June 3, 2021

3.5K

Related Concept Videos

Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...