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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

502
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Jun 4, 2025

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Trabecular meshwork ultrastructural changes in primary and secondary glaucoma.

Aparna Rao1,2, Tirupathi Rao3, Nagapriya Banka3

  • 1Glaucoma Service, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, 500034, India. aparna@lvpei.org.

Scientific Reports
|January 2, 2025
PubMed
Summary

Scanning electron microscopy revealed distinct ultrastructural changes in the trabecular meshwork (TM) of glaucoma patients. Primary glaucoma thins TM beams in the corneoscleral meshwork (CSM), while steroid and pseudoexfoliation glaucoma show unique deposits.

Keywords:
Primary glaucomaScanning electron microscopeSecondary glaucomaTrabecular meshworkUltrastructure

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Area of Science:

  • Ophthalmology
  • Cell Biology
  • Microscopy

Background:

  • The trabecular meshwork (TM) is crucial for aqueous humor outflow and intraocular pressure regulation.
  • Understanding TM ultrastructure is key to diagnosing and treating various glaucoma types.

Purpose of the Study:

  • To investigate and compare ultrastructural changes in the TM using scanning electron microscopy (SEM) across different glaucoma subtypes.
  • To differentiate TM morphology in primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG), pseudoexfoliation glaucoma (XFG), and steroid-induced glaucoma.

Main Methods:

  • Qualitative descriptive hospital-based study utilizing SEM on TM samples.
  • Samples obtained from 26 glaucoma patients (primary and secondary) and 10 controls.
  • Analysis focused on TM beams, corneoscleral meshwork (CSM), and juxtacanalicular (JCT) regions.

Main Results:

  • Primary glaucoma showed TM beam thinning, predominantly in the CSM, sparing the JCT.
  • PACG exhibited more rounded and thinner TM beams compared to POAG and XFG.
  • Steroid glaucoma revealed amorphous deposits; XFG displayed vesicular bodies on TM beams, distinct from controls.

Conclusions:

  • TM beam thinning in primary glaucoma primarily impacts the CSM region.
  • Unique ultrastructural findings in steroid-induced glaucoma and XFG suggest distinct pathological mechanisms.
  • SEM provides valuable insights into TM pathobiology for different glaucoma types.