Related Experiment Video
Updated: May 7, 2025
08:52
Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
17.1K
Cell therapies for viral diseases: a new frontier
David Nardo1, Emileigh G Maddox1, James L Riley2
1Department of Microbiology and Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Seminars in Immunopathology
|January 2, 2025
Summary
Cellular therapies offer a promising new approach to fighting viral infections by directing immune responses. This strategy holds potential for diseases lacking effective treatments or where pathogens persist, like HIV.
Area of Science:
- Immunology
- Virology
- Cellular Therapy
Background:
- Viral infections remain a significant global health threat despite medical advances.
- Current treatments like vaccines and small molecules are insufficient for some viral diseases, including HIV.
- Cellular therapies, successful in cancer treatment, offer a novel approach by leveraging immune system understanding.
Purpose of the Study:
- To review the application of cellular therapies in treating viral infections.
- To highlight the potential of cellular therapies in managing diseases with limited treatment options or persistent pathogens.
- To explore how cellular therapies can enhance or redirect immune responses against viruses.
Main Methods:
- Review of existing literature on cellular therapies for viral infections.
- Analysis of immune evasion strategies employed by viruses.
- Focus on the infusion of virus-specific immune cells.
Main Results:
- Cellular therapies demonstrate potential in controlling viral infections.
- Viruses evade immune responses through recognition avoidance or redirection of cellular actions.
- Infusing virus-specific immune cells can improve patient outcomes.
Conclusions:
- Cellular therapies represent a promising new modality for combating viral infections.
- This approach is particularly relevant for diseases with unmet treatment needs.
- Further investigation into virus-specific cellular therapies is warranted to enhance infection control strategies.
More Related Videos
11:18Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
Published on: May 7, 2012
12.7K
10:24Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System
Published on: October 5, 2015
12.3K
Related Concept Videos
01:27Tumor Immunotherapy
394
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
394
01:30Cancer Vaccines
237
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
237
00:59Gene Therapy
24.9K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
24.9K
02:49Cancer Therapies
7.4K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.4K
01:27Cytotoxic T Cells-mediated Immune Response
714
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
714
01:29Immune Response Against Viral Pathogens
443
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
443