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Diagnostic value of dual-layer spectral detector CT parameters for differentiating high- from low-grade bladder
Li Chen1, Lili Xu2, Xiaoxiao Zhang1
1Department of Radiology, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Objectives:
This study aimed to investigate the diagnostic value of spectral parameters of dual-layer spectral detector computed tomography (DLCT) in distinguishing between low- and high-grade bladder cancer (BCa).
Methods:
This single-center retrospective study included pathologically confirmed BCa patients who underwent preoperative contrast-enhanced DLCT. Patients were divided into low- and high-grade groups based on pathology. We measured and calculated the following spectral CT parameters: iodine density (ID), normalized ID (NID), arterial enhancement fraction (AEF), extracellular volume (ECV) fraction, virtual non-contrast (VNC), slope of the attenuation curve, and Z effective (Zeff). Univariate and multivariable logistic regression analyses were used to determine the best predictive factors in differentiating between low- and high-grade BCa. We used receiver operating characteristic curve analysis to assess diagnostic performance and decision curve analysis to determine the net benefit.
Results:
The study included 64 patients (mean age, 64 ± 11.0 years; 46 men), of whom 42 had high-grade BCa and 22 had low-grade BCa. Univariate analysis revealed that differences in ID and NID in the corticomedullary phase, AEF, ECV, VNC, and Zeff images were statistically significant (p = 0.001-0.048). Multivariable analysis found that AEF was the best predictor of high-grade tumors (p = 0.006). With AEF higher in high-grade BCa, AEF results were as follows: area under the curve (AUC), 0.924 (95% confidence interval, 0.861-0.988); sensitivity, 95.5%; specificity, 81.0%; and accuracy, 85.9%. The cutoff valve of AEF for predicting high-grade BCa was 67.7%.
Conclusion:
Using DLCT AEF could help distinguish high-grade from low-grade BCa.
Critical Relevance Statement:
This research demonstrates that the arterial enhancement fraction (AEF), a parameter derived from dual-layer spectral detector CT (DLCT), effectively distinguishes between high- and low-grade bladder cancer, thereby aiding in the selection of appropriate clinical treatment strategies.
Key Points:
This study investigated the value of dual-layer spectral detector CT in the assessment of bladder cancer (BCa) histological grade. The spectral parameter arterial enhancement fraction could help determine BCa grade. Our results can help clinicians formulate initial treatment strategies and improve prognostications.
