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Type 2 inflammation: a Portuguese consensus using Web-Delphi and decision conferencing (INFLAT2-PT).

Suzete Costa1,2, João Pedro Aguiar1,2, Mónica D Oliveira3,4

  • 1Institute for Evidence-Based Health (ISBE), Lisbon, Portugal.

Expert Review of Clinical Immunology
|January 3, 2025
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Summary
This summary is machine-generated.

This study developed expert consensus on type 2 inflammation diseases, including asthma and atopic dermatitis. The findings aim to improve understanding and multidisciplinary care for these growing public health concerns.

Keywords:
Allergyasthmaatopic dermatitischronic rhinosinusitisconsensuseosinophilic esophagitistype-2 inflammation

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Area of Science:

  • Allergy and Immunology
  • Public Health
  • Clinical Medicine

Background:

  • Atopic/allergic diseases represent a significant and increasing global public health challenge.
  • Type 2 inflammation underlies several interconnected conditions, contributing to multimorbidity.
  • A need exists for expert consensus on managing these complex diseases.

Purpose of the Study:

  • To establish a national expert consensus on clinical questions concerning type 2 inflammation.
  • To address the overlap and management of conditions driven by type 2 inflammation.
  • To provide evidence-based statements for improved patient care.

Main Methods:

  • A comprehensive literature review with qualitative analysis.
  • A modified 3-round Web-Delphi (e-Delphi) process.
  • A final online decision conference for expert agreement.

Main Results:

  • 30 consensus statements were generated with a high agreement rate (76% full agreement).
  • Statements cover pathophysiology, multimorbidity, diagnosis, management, and mental health impact.
  • Consensus includes conditions like asthma, atopic dermatitis, and eosinophilic esophagitis.

Conclusions:

  • The INFLAT2-PT consensus aims to enhance understanding of type 2 inflammation diseases.
  • It promotes multidisciplinary and integrated care approaches.
  • The consensus provides a foundation for future research and health policy informed by expert opinion.