Type 2 inflammation: a Portuguese consensus using Web-Delphi and decision conferencing (INFLAT2-PT).

Area of Science:

• Allergy and Immunology
• Public Health
• Clinical Medicine

Background:

• Atopic/allergic diseases represent a significant and increasing global public health challenge.
• Type 2 inflammation underlies several interconnected conditions, contributing to multimorbidity.
• A need exists for expert consensus on managing these complex diseases.

Purpose of the Study:

• To establish a national expert consensus on clinical questions concerning type 2 inflammation.
• To address the overlap and management of conditions driven by type 2 inflammation.
• To provide evidence-based statements for improved patient care.

Main Methods:

• A comprehensive literature review with qualitative analysis.
• A modified 3-round Web-Delphi (e-Delphi) process.
• A final online decision conference for expert agreement.

Main Results:

• 30 consensus statements were generated with a high agreement rate (76% full agreement).
• Statements cover pathophysiology, multimorbidity, diagnosis, management, and mental health impact.
• Consensus includes conditions like asthma, atopic dermatitis, and eosinophilic esophagitis.

Conclusions:

• The INFLAT2-PT consensus aims to enhance understanding of type 2 inflammation diseases.
• It promotes multidisciplinary and integrated care approaches.
• The consensus provides a foundation for future research and health policy informed by expert opinion.