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Bone Cells and Tissue

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...

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Related Experiment Video

Updated: Jun 23, 2026

Isolation, Processing and Analysis of Murine Gingival Cells

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

LepR-Expressing Cells in Bone and Periodontium.

Yue Li¹, Peitong Li¹, Kun Xue¹

¹State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

|January 3, 2025

Summary

Leptin receptor-expressing cells (LepR+ cells), a type of mesenchymal stem cell, are vital for bone and periodontal health. Targeting these cells shows promise for bone and periodontal repair and regeneration.

Keywords:

LepR bone periodontal tissue periodontitis regeneration stem cell

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Area of Science:

Stem cell biology
Regenerative medicine
Periodontology

Background:

LepR+ cells are a key mesenchymal stem cell subpopulation.
These cells are crucial for maintaining bone and periodontal homeostasis.
Recent research highlights their significance in tissue maintenance.

Purpose of the Study:

To review LepR+ cell roles in bone and periodontium.
To explore regulatory molecular mechanisms.
To assess therapeutic potential for bone/periodontal regeneration.

Main Methods:

Comprehensive literature review.
PubMed database search (last 20 years).
Synthesis of research on LepR+ cells in bone and periodontal tissues.

Main Results:

LepR+ cells exhibit self-renewal and multilineage differentiation.
They are essential for bone turnover and periodontal remodeling.
These cells are involved in fracture healing and show altered differentiation in diseases like osteoporosis and periodontitis.

Conclusions:

LepR+ cells are critical for bone and periodontal tissue repair.
Understanding their regulatory mechanisms is key.
Targeting LepR+ cell fate offers novel therapeutic strategies for regeneration.