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Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
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Low-density scalp electrical source imaging of the ictal onset zone network using source coherence maps
Parnia Sadeghzadeh1, Alexander Freibauer2, Rajesh RamachandranNair1
1Division of Neurology, Department of Pediatrics, McMaster Children's Hospital, Hamilton, ON, Canada.
Frontiers in Neurology
|January 3, 2025
Summary
Low-density scalp electrical source imaging using source coherence maps shows promise for identifying the seizure onset zone in pediatric epilepsy surgery. This non-invasive technique aids in guiding intracranial monitoring for better surgical outcomes.
Area of Science:
- Neuroscience
- Medical Imaging
- Epileptology
Background:
- Intracranial monitoring is the gold standard for identifying the epileptogenic zone in pediatric epilepsy surgery but has limited spatial resolution.
- Non-invasive techniques are needed to complement intracranial monitoring and improve the accuracy of pre-surgical evaluations.
Purpose of the Study:
- To investigate the utility of low-density scalp electrical source imaging with source coherence maps for identifying the ictal onset zone and interictal networks in pediatric epilepsy.
- To assess the concordance of source coherence maps with surgical resection margins and evaluate post-operative seizure freedom.
Main Methods:
- Retrospective review of 12 pediatric epilepsy patients who underwent focal resections.
- Generation of source coherence maps using low-resolution electromagnetic tomography.
- Assessment of outcomes at 3 years post-surgery, including seizure freedom.
Main Results:
- Ictal source coherence maps were generated for 7 patients, with 6 resections including the identified zone, leading to seizure freedom in 5 cases.
- Interictal spike ripple high-frequency oscillation networks using source coherence maps were analyzed in 3 patients, with 2 resections including the identified network and all 3 becoming seizure-free.
Conclusions:
- Low-density scalp electrical source imaging with source coherence maps shows proof of principle for identifying the ictal onset zone and interictal networks in pediatric epilepsy.
- This non-invasive method is a valuable adjunct to traditional electrical source imaging, potentially guiding electrode placement for intracranial monitoring and improving epileptogenic zone localization.
