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Related Experiment Videos

Metoclopramide-induced phantom dyskinesia.

J Jankovic, J P Glass

    Neurology
    |March 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    A patient developed movement disorders, including phantom limb chorea, after prolonged metoclopramide use for chemotherapy-induced nausea and vomiting. This case highlights potential neurological side effects of this antiemetic medication.

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    Area of Science:

    • Neurology
    • Pharmacology

    Background:

    • Metoclopramide is a commonly used antiemetic to manage chemotherapy-induced nausea and vomiting.
    • Prolonged use of metoclopramide has been associated with extrapyramidal side effects.

    Observation:

    • A 58-year-old woman received intravenous metoclopramide for two months during breast cancer chemotherapy.
    • She experienced acute onset of hand tremor, akathisia, and orofacial-truncal dyskinesia within hours of administration.

    Findings:

    • Following resolution of acute symptoms, the patient developed persistent shoulder stump chorea and phantom limb dystonia.
    • These included involuntary adduction and flexion of the phantom left arm and dystonic hand movements.

    Implications:

    • This case underscores the risk of persistent and complex movement disorders, including phantom limb dyskinesia, with extended metoclopramide treatment.

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  • Clinicians should be vigilant for neurological adverse events, even after initial symptom resolution, and consider alternative antiemetic strategies for long-term management.