Brugada Syndrome and Kawasaki Disease in a Two-Year-Old: A Case of Double Jeopardy

Brugada syndrome (BrS) is a genetic channelopathy that may predispose to ventricular arrhythmia. It is inherited as an autosomal dominant pattern with incomplete penetrance. Fever can unmask Brugada syndrome in children who have a genetic predisposition. Kawasaki disease is not known to be associated with Brugada syndrome; however, it may lead to cardiac complications such as coronary artery abnormalities and myocardial inflammation. We report a case of a two-year-old who was diagnosed with Kawasaki disease and subsequently developed Brugada syndrome.