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Atypical Cerebral Carcinoids Treated with Hippocampal-Sparing Whole Brain Radiotherapy
James A Knight1, Waleed F Mourad2, Hafsa Nebbache3
1Radiation Medicine, University of Kentucky, Lexington, USA.
Cureus
|January 3, 2025
Summary
Central nervous system metastases from atypical carcinoid tumors are rare. Hippocampal-sparing whole-brain radiotherapy (HS-WBRT) effectively controlled brain metastases while preserving cognitive function in a patient with atypical carcinoid.
Area of Science:
- Neuro-oncology
- Radiation Oncology
- Medical Oncology
Background:
- Central nervous system (CNS) metastases from atypical carcinoid tumors are exceptionally rare.
- Whole-brain radiotherapy (WBRT) offers survival benefits but can impair long-term memory and executive function.
- Atypical carcinoid tumors can metastasize to the liver and brain despite systemic therapy.

