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Clade Ib: a new emerging threat in the Mpox outbreak

Shriyansh Srivastava1,2, Laxmi1, Khyati Sharma1

  • 1Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, India.

Frontiers in Pharmacology
|January 3, 2025
PubMed

Insights

The novel Monkeypox virus (MPXV) clade Ib poses a significant public health threat. This review details its transmission, clinical features, and detection, emphasizing global collaboration for containment.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Monkeypox (Mpox) is a zoonotic disease caused by the Monkeypox virus (MPXV) in the Orthopoxvirus genus.
  • The recent global Mpox outbreak features a novel, potentially severe clade Ib.
  • Understanding clade Ib dynamics is crucial for public health response.

Purpose of the Study:

  • To comprehensively review the emergence, characteristics, and impact of MPXV clade Ib.
  • To analyze transmission, clinical presentation, diagnostics, and treatment strategies for clade Ib.
  • To identify research gaps and emphasize global collaboration for Mpox control.

Main Methods:

  • Systematic literature review of MPXV clade Ib.
  • Analysis of epidemiological data, clinical case studies, and genetic information.
  • Evaluation of diagnostic, prevention, and treatment modalities.

Main Results:

  • Clade Ib exhibits distinct genetic traits and epidemiological impact compared to other clades.
  • Key risk factors for MPXV transmission and person-to-person spread are identified.
  • Current diagnostic and surveillance methods require enhancement for clade Ib detection.

Conclusions:

  • Global collaboration and enhanced surveillance are critical for managing the MPXV clade Ib threat.
  • Further research is needed to address knowledge gaps in Mpox prevention and treatment.
  • AI applications show promise in improving outbreak management and response strategies.
Keywords:
clade Ibemerging threatoutbreakspreventionsurveillancetransmission

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