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Clade Ib: a new emerging threat in the Mpox outbreak
Shriyansh Srivastava1,2, Laxmi1, Khyati Sharma1
1Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, India.
Frontiers in Pharmacology
|January 3, 2025
Summary
The novel Monkeypox virus (MPXV) clade Ib poses a significant public health threat. This review details its transmission, clinical features, and detection, emphasizing global collaboration for containment.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Monkeypox (Mpox) is a zoonotic disease caused by the Monkeypox virus (MPXV) in the Orthopoxvirus genus.
- The recent global Mpox outbreak features a novel, potentially severe clade Ib.
- Understanding clade Ib dynamics is crucial for public health response.
Purpose of the Study:
- To comprehensively review the emergence, characteristics, and impact of MPXV clade Ib.
- To analyze transmission, clinical presentation, diagnostics, and treatment strategies for clade Ib.
- To identify research gaps and emphasize global collaboration for Mpox control.
Main Methods:
- Systematic literature review of MPXV clade Ib.
- Analysis of epidemiological data, clinical case studies, and genetic information.
- Evaluation of diagnostic, prevention, and treatment modalities.
Main Results:
- Clade Ib exhibits distinct genetic traits and epidemiological impact compared to other clades.
- Key risk factors for MPXV transmission and person-to-person spread are identified.
- Current diagnostic and surveillance methods require enhancement for clade Ib detection.
Conclusions:
- Global collaboration and enhanced surveillance are critical for managing the MPXV clade Ib threat.
- Further research is needed to address knowledge gaps in Mpox prevention and treatment.
- AI applications show promise in improving outbreak management and response strategies.
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