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Updated: Jun 4, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Chiral synthetic hosts for efficient enantioselective molecular recognition. Design principles and synthetic aspects
Hugo Marchi Luciano1, Agustí Lledó1,2
1Institut de Química Computacional i Catàlisi (IQCC), Universitat de Girona, Maria Aurèlia Capmany 69, 17003 Girona, Spain. agusti.lledo@udg.edu.
Abstract:
Discrimination of enantiomeric substrate molecules is one of the fundamental properties of biological hosts. Replicating enantioselective molecular recognition with synthetic receptors is a topic of interest with implications in diverse applications such as bioinspired enantioselective catalysis, enantiomer separation, or sensing. In this review, five different systems reported in the literature are discussed, and their performance and versatility are analyzed. A recently reported host featuring a flexible scaffold challenges the long-established view that a high degree of preorganization in combination with strongly directional non-covalent interactions is required for efficient enantiodiscrimination. The review is complemented with an analysis of the synthetic effort required for each of the hosts presented.
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