Hypoxia studies in non‑small cell lung cancer: Pathogenesis and clinical implications (Review)
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View abstract on PubMed
Summary
This summary is machine-generated.Hypoxia, or low oxygen, significantly drives non-small cell lung cancer (NSCLC) progression, promoting tumor growth, metastasis, and resistance to therapies. Targeting hypoxia offers a promising strategy for improved NSCLC treatment.
Area Of Science
- Oncology
- Cancer Biology
- Tumor Microenvironment
Background
- Non-small cell lung cancer (NSCLC) presents a major global health challenge with poor prognosis despite advancements in treatment.
- The hypoxic microenvironment is a critical factor in tumor progression and treatment resistance in NSCLC.
Purpose Of The Study
- To systematically review the multifaceted role of the hypoxic microenvironment in NSCLC progression.
- To explore how hypoxia influences tumor growth, invasion, metastasis, and therapeutic resistance in NSCLC.
Main Methods
- Systematic review of existing literature on hypoxia in NSCLC.
- Analysis of molecular mechanisms underlying hypoxia-driven tumor behavior.
Main Results
- Hypoxia promotes NSCLC cell growth, invasion, and metastasis.
- Hypoxia enhances tumor resistance to immunotherapy, radiotherapy, and chemotherapy via pathways including HIF activation and metabolic reprogramming.
- Hypoxia facilitates immune escape by modulating the tumor immune microenvironment.
Conclusions
- The hypoxic microenvironment is a key driver of NSCLC progression and therapeutic resistance.
- Targeting cellular hypoxia and developing hypoxia-based therapies represent a promising avenue for precision treatment in NSCLC.
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