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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Updated: Jun 4, 2025

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Topical Netarsudil in Childhood Glaucoma: A Systematic Review.

Omar Shaikh1, Lana Kuziez2, Osamah J Saeedi3

  • 1University of Texas Southwestern Medical Center, Dallas, TX, USA.

Current Eye Research
|January 3, 2025
PubMed
Summary

Topical netarsudil 0.02% shows potential as an adjunctive treatment for childhood glaucoma, possibly delaying surgery. However, careful monitoring for adverse events like hyperemia and corneal changes is essential.

Keywords:
GlaucomaNetarsudilRhopressachildhoodpediatric

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Area of Science:

  • Ophthalmology
  • Pediatric Medicine
  • Pharmacology

Background:

  • Childhood glaucoma presents unique management challenges.
  • Limited treatment options exist for refractory pediatric glaucoma cases.
  • Topical netarsudil offers a novel mechanism of action targeting Rho-kinase.

Purpose of the Study:

  • To evaluate the efficacy and safety of topical netarsudil 0.02% in pediatric glaucoma management.
  • To synthesize current evidence on netarsudil use in childhood glaucoma.

Main Methods:

  • A comprehensive literature search was conducted across major electronic databases (PubMed CENTRAL, Google Scholar, EMBASE, RCT, Ovid MEDLINE) from January 2017 to August 2023.
  • Keywords included "netarsudil," "rhopressa," "Rho-kinase," "pediatric glaucoma," "childhood glaucoma," and "intraocular pressure."
  • Eight publications (4 retrospective, 1 prospective, 3 case reports) were analyzed.

Main Results:

  • Studies included a heterogeneous cohort of primary and secondary childhood glaucoma with follow-up ranging from 1 week to 26 months.
  • Mean intraocular pressure (IOP) reduction varied, with reported reductions from 0.8 ± 13.2 to 12.0 ± 0.0 mmHg.
  • The most frequent adverse events were conjunctival hyperemia (32.9%) and corneal honeycombing/reticular epithelial edema (15.9%).

Conclusions:

  • Current literature on topical netarsudil for childhood glaucoma is limited.
  • Netarsudil may be a valuable adjunctive therapy for refractory pediatric glaucoma, potentially postponing surgical intervention.
  • Close corneal monitoring is crucial to detect and manage adverse events promptly.