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Related Experiment Video

Updated: May 7, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

123

Association Between Average Daily Activity Counts and Knee Osteoarthritis Progression.

Xiaozhen Tang, Dongze Li1, Haishan Yao1

  • 1Department of Orthopaedics, The No.903 Hospital of PLA Joint Logistic Support Force, Hangzhou, China.

American Journal of Physical Medicine & Rehabilitation
|January 3, 2025
PubMed
Summary
This summary is machine-generated.

Moderate daily activity may protect against knee osteoarthritis (OA) progression. Both low and high activity levels may increase OA risk, suggesting tailored exercise recommendations are needed for individuals with or at risk for knee OA.

Keywords:
Daily Activity CountsDose-ResponseKnee Osteoarthritis ProgressionOptimal ThresholdRestricted Cubic Spline

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Area of Science:

  • Orthopedics
  • Biomedical Engineering
  • Physical Therapy

Background:

  • Knee osteoarthritis (OA) is a prevalent degenerative joint disease.
  • Understanding the impact of physical activity on OA progression is crucial for management.
  • Current recommendations for physical activity in knee OA patients lack specific thresholds.

Purpose of the Study:

  • To investigate the dose-response relationship between daily physical activity counts and knee OA progression.
  • To identify potential optimal activity thresholds for mitigating OA progression.

Main Methods:

  • A cohort study utilizing data from the Osteoarthritis Initiative (OAI) was conducted.
  • 610 participants aged 45-79 with knee OA or at risk were included.
  • Daily activity was measured using accelerometers, and OA progression was assessed via Kellgren-Lawrence (KL) grade and joint space narrowing (JSN) scores over two years.

Main Results:

  • A U-shaped relationship was observed between daily activity counts and knee OA progression.
  • Moderate activity levels (below 3263.3 counts/min) were associated with reduced risk of KL-grade and JSN-score progression.
  • Both very low and high activity levels were linked to an increased risk of OA progression.

Conclusions:

  • Moderate physical activity may offer a protective effect against knee OA progression.
  • Both insufficient and excessive physical activity may exacerbate knee OA.
  • Personalized physical activity guidelines are necessary for individuals with or at risk of knee OA.