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[Anti-T in children].

A Sedlmayer, C de Fenoyl, A Hajek-Rosenmayr

    Padiatrie Und Padologie
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Anti-T antibodies were found in 24.8% of newborns, potentially causing hemolysis. Antibody levels in children aged 1-17 years reached adult levels by age four.

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    Area of Science:

    • Immunology
    • Pediatrics
    • Transfusion Medicine

    Background:

    • The Thomsen-Friedenreich antigen (T-antigen) is a significant red blood cell antigen.
    • Anti-T antibodies can be associated with hemolytic transfusion reactions and autoimmune hemolytic anemia.

    Purpose of the Study:

    • To determine the prevalence of anti-T antibodies in different age groups, including newborns, children, and adults.
    • To investigate the potential role of anti-T antibodies in neonatal hemolysis.
    • To understand the developmental trajectory of anti-T antibody levels from infancy to adulthood.

    Main Methods:

    • Sera from 245 newborns, 165 older children (1-17 years), and 50 adults were analyzed.
    • Antibody levels against the T-antigen were quantified using serological methods.

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    Main Results:

    • Anti-T antibodies were detected in 24.8% of newborn sera.
    • The presence of anti-T antibodies in newborns may explain previously unexplained hemolytic episodes.
    • Anti-T antibody levels in children aged 1 year were comparable to adult levels by age 4.

    Conclusions:

    • Neonates can possess anti-T antibodies, suggesting a potential link to hemolysis in this population.
    • The development of anti-T antibody levels is a progressive process during childhood, reaching adult levels by age four.