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Amifloxacin distribution in the dog prostate
The Prostate
|January 1, 1985
Summary
Amifloxacin concentrations in prostatic fluid and tissue were lower than plasma but still exceeded minimal inhibitory concentrations for bacteria causing chronic bacterial prostatitis in dogs. Further clinical trials are warranted.
Area of Science:
- Pharmacology
- Urology
- Infectious Diseases
Background:
- Chronic bacterial prostatitis is often caused by gram-positive bacteria.
- Effective drug delivery to prostatic tissues is crucial for treatment.
- Amifloxacin is a quinoline carboxylic acid derivative with potential antibacterial properties.
Purpose of the Study:
- To determine amifloxacin distribution in canine prostate.
- To evaluate amifloxacin concentrations in prostatic secretion (PS), prostatic interstitial fluid (PIF), prostatic tissue, and plasma (P).
Main Methods:
- Constant infusion of amifloxacin in anesthetized dogs under steady-state conditions.
- Measurement of drug concentrations in PS, PIF, prostatic tissue, and plasma.
Main Results:
- Amifloxacin concentrations in PS and PIF were lower than in plasma (P).
- PS/P and PIF/P concentration ratios did not exceed 1.0.
- Prostatic amifloxacin levels were above minimal inhibitory concentrations for common prostatitis pathogens.
Conclusions:
- Amifloxacin penetrates canine prostatic tissues and fluids.
- Achieved concentrations suggest potential efficacy against chronic bacterial prostatitis.
- Clinical trials of amifloxacin for prostatitis are justified.