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Updated: Jun 4, 2025

Author Spotlight: Investigating Angiogenesis Through Challenges and Innovations in Assay Development
Published on: May 31, 2024
A novel quantitative angiogenesis assay based on visualized vascular organoid
Yun Zhao1, Mengze Sun1, Zihang Pan1
1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Clinical Stem Cell Research Center, Peking University Third Hospital, Peking University, Beijing, 100191, China.
Researchers developed a novel human pluripotent stem cell (hPSC) model for high-throughput drug screening. This platform accurately visualizes and quantifies angiogenesis, aiding in the discovery of new therapies for diseases like cancer and diabetes.
Area of Science:
- Biomedical Engineering
- Stem Cell Biology
- Vascular Biology
Background:
- Angiogenesis, the formation of new blood vessels, is crucial in diseases like cancer and diabetes.
- Current anti-angiogenic therapies targeting VEGF lack specificity and efficacy.
- There is a need for robust in vitro models for high-throughput drug screening.
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