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Point prevalence survey of antibiotic use in Mexican secondary care hospitals
Federico A Zumaya-Estrada1, Celia M Alpuche-Aranda1, Hilda Ivonne Huerta Icelo1
1National Institute of Public Health of Mexico, Center for Infectious Diseases Research, Cuernavaca, Morelos, Mexico.
Introduction:
Tackling the inertia of growing threat of antimicrobial resistance (AMR) requires changes in how antibiotics are prescribed and utilized. The monitoring of antimicrobial prescribing in hospitals is a critical component in optimizing antibiotic use. Point prevalence surveys (PPSs) enable the surveillance of antibiotic prescribing at the patient level in small hospitals that lack the resources to establish antimicrobial stewardship programs (ASP). In this study, we analyzed antibiotic use at two public secondary care hospitals in Mexico using PPSs.
Methods:
Following WHO methodology, we conducted four cross-sectional PPSs on antibiotic use in two public secondary care facilities in Mexico: two surveys in a women's specialty hospital (H1) and two in a general referral hospital (H2). We collected data from clinical records of all patients with active antibiotic prescriptions (APs) across the medical, surgical, and mixed (MIX) wards, and intensive care units (ICUs). Descriptive statistics were computed to analyze the PPSs data using Stata.
Results:
The PPSs collected data on 127 patients, and 283 active APs. The prevalence of antibiotic use was 60.4% (H1, n = 29/48) and 70.5% (H2, n = 98/139). Antibiotics were more frequently used among patients in the MIX wards (H1: 87.5%, n = 14/16) and ICUs (H2: 90%, n = 9/10). The most frequent patient indications for antibiotic use were medical prophylaxis (H1: 51.7%, n = 15/29), community-acquired infections (H2: 42.9%, n = 42/98), and preoperative prophylaxis (H1: 27.6%, n = 8/29; H2: 23.5%, n = 23/98). The APs were mostly empirical (H1: 97%, n = 64/66; H2: 98.2%, n = 213/217), and parenterally administered (H1: 90.9%, n = 60/66; H2: 96.8%, n = 210/217). Most clinical records lacked documented post-prescription reviews (H1: 82.8%, n = 24/29; H2: 98%, n = 96/98). Preoperative prophylaxis was predominantly administered as multiple doses for more than one day. Penicillins with extended-spectrum (24.2%, n = 16/66), aminoglycosides (22.7%, n = 15/66), and first-generation cephalosporins (16.7%, n = 11/66) were the most prescribed antibiotic classes in H1, while third-generation cephalosporins (35%, n = 76/217), fluoroquinolones (14.3%, n = 31/217), and carbapenems (13.4%, n = 29/217) were the most prescribed in H2. No hospital had formally established ASP.
Conclusions:
This study shows high prevalence rates of antibiotic use and variations in commonly prescribed antibiotic classes in public Mexican secondary care hospitals, along with shared practices in broad-spectrum antibiotic prescription. PPS-based surveillance enables the identification of specific targets to optimize antibiotic use according to the healthcare needs of patients in each hospital and facilitates comparative evaluations across hospitals.
Insights
High antibiotic use was observed in Mexican hospitals, with variations in prescribing patterns. Point prevalence surveys (PPSs) help identify targets for optimizing antibiotic use and improving patient care.
Area of Science:
- Infectious Diseases
- Public Health
- Pharmacology
Background:
- Antimicrobial resistance (AMR) is a growing global threat requiring optimized antibiotic prescribing.
- Monitoring antibiotic use in hospitals is crucial for effective antimicrobial stewardship programs (ASP).
- Point prevalence surveys (PPSs) are valuable tools for antibiotic surveillance in hospitals lacking formal ASPs.
Purpose of the Study:
- To analyze antibiotic prescribing and utilization patterns in two public secondary care hospitals in Mexico.
- To identify specific targets for optimizing antibiotic use through PPS-based surveillance.
Main Methods:
- Four cross-sectional point prevalence surveys (PPSs) were conducted following WHO methodology.
- Data were collected from clinical records of patients with active antibiotic prescriptions (APs) in medical, surgical, mixed wards, and ICUs.
- Descriptive statistics were used to analyze the collected PPS data.
Main Results:
- Antibiotic use prevalence was 60.4% in H1 and 70.5% in H2.
- Antibiotics were most frequently used for medical prophylaxis and community-acquired infections.
- Prescriptions were predominantly empirical and parenteral, with frequent use of broad-spectrum agents and limited documentation of post-prescription reviews.
Conclusions:
- High antibiotic use prevalence and varied prescribing patterns were observed in Mexican secondary care hospitals.
- PPS-based surveillance effectively identifies targets for optimizing antibiotic use tailored to hospital-specific needs.
- Comparative evaluations across hospitals can be facilitated by PPS data.
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