Related Experiment Video
Updated: Jun 4, 2025
11:52
Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors
Published on: June 18, 2013
11.0K
Intelligent Hierarchical Targeting Near-Infrared Persistent Luminescence Nanosystem for Improved Nuclear Delivery and
Yunfei Zhu1, Ya Wen2, Yanping Xie2
1Ministry of Education Key Laboratory of Bioinorganic and Synthetic Chemistry, State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China.
ACS Applied Materials & Interfaces
|January 3, 2025
Summary
A novel theranostic nanosystem targets Epstein-Barr virus (EBV) oncoproteins, delivering EBNA1 inhibitors to treat EBV-associated cancers. This system offers dual targeting and near-infrared imaging for enhanced therapeutic efficacy.
Area of Science:
- Nanotechnology for targeted cancer therapy
- Molecular virology and oncology
- Theranostic systems for imaging and treatment
Background:
- Epstein-Barr virus nuclear antigen 1 (EBNA1) is crucial for EBV replication and a target for treating EBV-associated cancers.
- Existing EBNA1 inhibitors lack effective in vivo delivery strategies.
- Theranostic nanosystems offer potential for combined diagnosis and therapy.
Purpose of the Study:
- To develop an intelligent hierarchical targeting theranostic nanosystem (mZGOCS@MnO2-P5) for EBV-associated cancers.
- To enable targeted delivery of EBNA1 inhibitors and simultaneous imaging of delivery efficacy.
- To evaluate the in vitro and in vivo feasibility of the nanosystem for cancer therapy.
Main Methods:
- Constructed a nanosystem integrating a dual-targeting peptide (N3-P5), a tumor microenvironment-responsive MnO2 nanosheet, and a NIR-PL nanosphere (mZGOCS).
- Utilized P5 peptide for hierarchical targeting of LMP1 and EBNA1.
- Leveraged MnO2 degradation in the tumor microenvironment to release P5 and enable NIR-PL imaging.
Main Results:
- The mZGOCS@MnO2-P5 system demonstrated hierarchical targeting of LMP1 and EBNA1.
- MnO2 degradation in the tumor microenvironment triggered P5 release and NIR-PL signal recovery.
- The nanosystem effectively inhibited EBV-positive tumor growth in vitro and in vivo.
Conclusions:
- The developed hierarchical targeting theranostic nanosystem (mZGOCS@MnO2-P5) shows promise for EBV-associated cancer therapy.
- The system integrates targeted drug delivery, responsive drug release, and non-invasive imaging.
- This approach highlights significant translational potential for treating EBV-related malignancies.
