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Plasma cell and cancer stem cell crosstalk in glioblastoma

Elijah Kirschstein1, Andrew J Gunderson1

  • 1Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Department of Surgery, The Ohio State University, Columbus, OH 43210, USA.

Cancer Cell
|January 3, 2025
PubMed

Plasma cells (PCs) are the main producers of antibodies and have context-dependent roles in tumor immunity. In this issue of Cancer Cell, Gao et al. report that intratumoral PCs drive maintenance of glioblastoma stem cells to promote tumor growth via IgG secretion that activates a FcγRIIA-SYK-AKT signaling axis.

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