Related Experiment Video
Updated: May 7, 2025

Author Spotlight: Advancing Fertility Assessment with Z-Score-Based Follicle Density Evaluation in Cryopreserved Ovarian Tissue
Published on: October 25, 2024
Bona fide diminished ovarian reserve or profound ovarian suppression by long-term oral contraceptive use?
1Reproductive Medicine, Weill Cornell Medicine, New York, New York, USA.
Abstract:
Combined oral contraceptives (COCs) are widely used by reproductive-aged women. Current data suggest that long-term use of COCs can suppress ovarian reserve markers, including anti-mullerian hormone and antral follicle count, which may negatively impact ovarian response and oocyte yield in patients undergoing planned oocyte cryopreservation to preserve future reproductive potential. Discontinuation of COCs can improve ovarian stimulation outcomes, though the ideal duration of cessation is unknown. In this case report, we describe a patient with profound ovarian suppression from long-term COC use and her delayed reversal in ovarian suppression as demonstrated by longitudinal assessment of ovarian reserve markers and ovarian stimulation outcomes.
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