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Updated: Jun 4, 2025

Simultaneous Isolation and Culture of Atrial Myocytes, Ventricular Myocytes, and Non-Myocytes from an Adult Mouse Heart
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Circadian biology of cardiac aging

Sharanya S Bettadapura1, William D Todd2, Graham R McGinnis3

  • 1Kinesiology & Health, University of Wyoming, Laramie, WY, USA.

Journal of Molecular and Cellular Cardiology
|January 3, 2025
PubMed

Insights

As the U.S. population ages, cardiovascular disease rises. This review explores how aging disrupts the heart

Area of Science:

  • Cardiovascular Biology
  • Gerontology
  • Chronobiology

Background:

  • The U.S. population is aging, leading to increased age-related cardiovascular disease.
  • Circadian rhythms are vital for health but are impaired by aging and heart disease.

Purpose of the Study:

  • To review changes in cardiac circadian rhythms with aging.
  • To examine the link between cardiac aging and heart disease.
  • To explore interventions for aging and their impact on cardiac clock function.

Main Methods:

  • Literature review of studies on aging, circadian rhythms, and cardiovascular disease.
  • Analysis of the impact of aging on cardiac clock mechanisms.
  • Evaluation of potential chronotherapeutic interventions.

Main Results:

  • Aging alters cardiac circadian rhythms, potentially contributing to heart disease.
  • Interventions targeting aging may affect cardiac clock function.
  • Chronotherapy might offer benefits for cardiac function in aging.

Conclusions:

  • Altered circadian clock output is a hallmark of aging.
  • Restoring cardiac clock function is crucial for healthy cardiac aging.
  • Further research is needed to understand and target cardiac circadian biology in aging.

Keywords:
Cardiac agingCircadian rhythmsExercise

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