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Clinical Characteristics, Risk Factors and Outcomes of Invasive Fungal Disease in Critically III Patients with

Changzhen Yang1, Jie Xiong2, Jiakai Wang1

  • 1Department of Intensive Care Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.

Clinical Lymphoma, Myeloma & Leukemia
|January 3, 2025
PubMed
Abstract

Insights

Invasive fungal disease (IFD) is common in critically ill patients with hematological malignancies (HM), leading to longer ICU stays. Hypertension and prolonged mechanical ventilation are key risk factors for IFD.

Area of Science:

  • Critical Care Medicine
  • Hematology
  • Infectious Diseases

Background:

  • Invasive fungal disease (IFD) presents significant challenges for critically ill patients with hematological malignancies (HM).
  • Limited research exists on IFD's clinical characteristics, risk factors, and outcomes in this specific patient group.

Purpose of the Study:

  • To investigate the clinical characteristics, risk factors, and outcomes of IFD in critically ill patients with HM.
  • To identify independent risk factors associated with IFD development in this vulnerable population.

Main Methods:

  • Retrospective study conducted at a tertiary center in China.
  • Inclusion of patients with HM admitted to the intensive care unit (ICU) between 2014 and 2022.
  • Analysis of patient data to determine IFD prevalence, characteristics, and associated factors.

Main Results:

  • IFD was diagnosed in 43.9% of 239 enrolled patients.
  • Patients with IFD experienced significantly longer ICU stays (median 4.9 vs. 2.9 days).
  • Hypertension, mechanical ventilation >48 hours, and delayed ICU transfer were independent IFD risk factors.

Conclusions:

  • IFD is a frequent complication in critically ill HM patients, correlating with extended ICU length of stay.
  • Hypertension, prolonged mechanical ventilation, and delayed ICU transfer are identified as independent risk factors for IFD.
  • Findings highlight the need for targeted preventive strategies and early detection in this high-risk group.
Keywords:
Acute lymphoblastic leukemiaAcute myeloid leukemiaFungal ecologyHypertensionIntensive care unit (ICU)Mortality

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