Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Three-Dimensional Microscopy in Microbiology01:28

Three-Dimensional Microscopy in Microbiology

907
Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
907

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design of active pharmaceutical ingredient-ionic liquids for enhanced delivery to skin.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Fabrication of Microneedle Patches by Suspension Casting of Drugs in Organic Solvents.

Pharmaceutics·2026
Same author

Correction to "Conductive Microneedle Patch with Electricity-Triggered Drug Release Performance for Atopic Dermatitis Treatment".

ACS applied materials & interfaces·2026
Same author

Noninvasive Monitoring of Skin pH Changes Induced by Microneedle Electroporation.

Sensors and actuators. B, Chemical·2026
Same author

Microneedle array platforms for drug delivery and biomarker sensing: From skin mechanics guided design to scalable manufacture for clinical utility.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Near-infrared light-activated lidocaine microneedle patch for rapid local anesthesia.

Theranostics·2026
Same journal

Repurposing Non-oncologic Drugs via Targeted Nanocarriers for Cancer Therapy: Mechanisms, Synergistic Combinations, and Clinical Translation.

AAPS PharmSciTech·2026
Same journal

Targeting Permeability Barriers By Strategic Selection of Thiol Containing Coformer for Novel Cocrystals of Metformin.

AAPS PharmSciTech·2026
Same journal

Plume Geometry Matters: Investigating the Contribution of Mass-Based Plume Geometry to Aerosol Delivery Efficiency in pMDIs.

AAPS PharmSciTech·2026
Same journal

Eigenrate-Based Thermodynamic Decomposition of Competing Release Mechanisms in Polymeric Nano- and Microspheres: The MMIR-S Framework with Arrhenius Dual-Population Burst Kinetics and Log-Normal Polydispersity Averaging.

AAPS PharmSciTech·2026
Same journal

Charge-Interaction-Mediated Adsorption of Human Growth Hormone on Polymeric Nanoparticles.

AAPS PharmSciTech·2026
Same journal

Development and Characterization of Amorphous PVP K30-Phosphatidylcholine Dispersions for the Fixed-Dose Co-Delivery of Hesperetin and Cannabidiol Prepared by Hot-Melt Extrusion.

AAPS PharmSciTech·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.3K

Multi-Layered Microneedles Loaded with Microspheres.

Andrew R Tadros1, Xin Dong Guo1, Mark R Prausnitz2

  • 1School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, Georgia, 30332-0100, U.S.A.

AAPS Pharmscitech
|January 3, 2025
PubMed
Summary
This summary is machine-generated.

Microneedle (MN) patches loaded with biodegradable microspheres offer controlled, sustained drug delivery through the skin barrier. This innovative technology enables targeted therapy administration lasting over 45 days.

Keywords:
PLGA microspherecontrolled releasedermatologymicroneedle patchpolylactic-co-glycolic acidskintransdermal drug delivery

More Related Videos

Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.0K
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.0K

Related Experiment Videos

Last Updated: May 4, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.3K
Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.0K
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.0K

Area of Science:

  • Biomaterials Science
  • Dermal Drug Delivery
  • Nanotechnology

Background:

  • The stratum corneum presents a significant barrier to effective transdermal therapy delivery.
  • Microneedle (MN) patches offer a promising avenue for non-invasive skin drug delivery.
  • Biodegradable polymer formulations can enable controlled drug release from MNs.

Purpose of the Study:

  • To enhance the spatiotemporal control of therapy delivery using MN patches.
  • To develop multi-layered MN patches incorporating biodegradable microspheres for sustained release.
  • To investigate the feasibility of microsphere-loaded MNs for transdermal drug administration.

Main Methods:

  • Polylactic-co-glycolic acid (PLGA) microspheres were fabricated to encapsulate a model dye.
  • Layer-by-layer fabrication was employed to create multi-layered MN patches loaded with PLGA microspheres.
  • Mechanical properties of MNs were assessed, and ex vivo/in vivo skin insertion studies were performed.

Main Results:

  • MN patches were successfully loaded with up to 5 μg/MN of PLGA microspheres.
  • Increasing microsphere layers reduced the mechanical strength of the MNs.
  • Microsphere-loaded MN patches dissolved within 15 minutes in porcine and murine skin, initiating controlled release over 45 days.

Conclusions:

  • Multi-layered, microsphere-loaded MN patches are feasible for targeted and sustained transdermal therapy delivery.
  • This technology addresses the limitations of the stratum corneum barrier for medical applications.
  • The developed MN patches demonstrate potential for advanced vaccination and dermatological treatments.