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Setting sights on a single-shot malaria vaccine

Debashree Goswami1, Stefan H I Kappe2,3

  • 1Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.

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PubMed
Summary

No abstract available in PubMed .

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Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

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