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Management of Philadelphia Chromosome-Positive B-Lymphoblastic Leukemia Diagnosed in an Infant

Jessica A O Zimmerman1, Jason Cleppe2, David S Dickens1

  • 1Division of Pediatric Hematology/Oncology, Stead Family Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA.

Pediatric Blood & Cancer
|January 4, 2025
PubMed
Abstract

No abstract available in PubMed .

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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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