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Precision tumor treatment utilizing bacteria: principles and future perspectives.

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  • 1Department of Ultrasound Medicine, The Second Affiliated Hospital of Air Force Medical University, No.569 Xinsi Road, Xi'an, 710038, Shaanxi, China.

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Engineered bacteria offer a promising strategy for cancer treatment by targeting tumors, delivering therapies, and stimulating immune responses. Integrating synthetic biology and nanomedicine enhances their effectiveness and control for future clinical applications.

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Area of Science:

  • Oncology
  • Microbiology
  • Biotechnology

Background:

  • Bacteria-based tumor therapy is an emerging strategy that utilizes engineered bacteria to target and treat tumors.
  • These bacteria can be modified to release therapeutic agents, remodel the tumor microenvironment, kill cancer cells, and activate anti-tumor immunity.

Purpose of the Study:

  • To provide a comprehensive review of bacteria-based tumor therapy.
  • To elucidate bacterial gene expression induction systems and nanobiohybrid construction strategies.
  • To discuss challenges and future prospects for clinical translation.

Main Methods:

  • Systematic review of current research on engineered bacteria for cancer therapy.
  • Analysis of bacterial gene engineering techniques for tumor targeting and immune activation.
  • Exploration of synthetic biology and nanomedicine integration for enhanced bacterial therapeutics.

Main Results:

  • Engineered bacteria demonstrate potential for tumor targeting, payload delivery, and immune modulation.
  • Bacterial gene expression induction systems and nanobiohybrid strategies are key to enhancing therapeutic efficacy.
  • Significant progress has been made in developing controllable and effective bacteria-based cancer treatments.

Conclusions:

  • Bacteria-based tumor therapy holds significant promise as a novel cancer treatment modality.
  • Further research into quality control, regulation, and clinical translation is essential.
  • The integration of advanced technologies will drive the future development of this therapeutic approach.