Related Experiment Video
Updated: May 7, 2025

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
Causal associations between circulating protein ratios and drug resistance in papillary thyroid cancer: a Mendelian
Jiaqin Deng1, Ming Yu2, Yihua Gu2
1Department of Thyroid Surgery, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, No. 63 Huangtang Road, Meijiang District, Meizhou, 514000, People's Republic of China. dengjiaqin666@163.com.
Objective:
Circulating protein level ratios (CPLRs) may play a crucial role in tumor progression and drug resistance by mediating interactions within the tumor microenvironment. This study aims to investigate the causal associations between CPLRs and papillary thyroid cancer (PTC), focusing on their potential implications in drug resistance mechanisms.
Methods:
Genetic data for 2821 CPLRs were obtained from the GWAS and FinnGen databases. Mendelian randomization (MR) analysis, using inverse variance weighting (IVW) as the primary method, was conducted to explore causality. Sensitivity analyses, including heterogeneity and pleiotropy tests, were performed to ensure the robustness of the results.
Results:
Twelve CPLRs were identified as causally associated with PTC. Seven CPLRs, such as REG1A/TFF3 and LAT/SPARC, were associated with reduced PTC risk, potentially reflecting protective mechanisms. In contrast, five CPLRs, including MAD1L1/PSIP1 and CIAPIN1/TYMP, were linked to increased risk, suggesting their role in promoting drug resistance. Reverse MR analysis revealed no significant causal associations, reinforcing the directionality of these findings.
Conclusion:
These findings highlight the relevance of CPLRs in the pathogenesis and drug resistance of PTC, providing insights into potential biomarkers and therapeutic targets. Future research could focus on translating these findings into strategies for personalized medicine and targeted treatment.
Related Concept Videos
Treatment Resistant Cancers
Factors Affecting Protein-Drug Binding: Patient-Related Factors
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Physiological Pharmacokinetic Models: Assumption with Protein Binding

