CT-based airway changes after smoking cessation in the general population
Ivan Dudurych1, Grigory Sidorenkov2, Marcel van Tuinen1
1Department of Radiology, University Medical Centre Groningen, Groningen, the Netherlands.
European Journal of Radiology
|January 4, 2025
Summary
For ex-smokers with respiratory conditions, longer smoking cessation is linked to reduced bronchial wall area percent. This suggests potential airway health improvements after quitting smoking.
Area of Science:
- Pulmonary Medicine
- Radiology
- Respiratory Health
Background:
- Previous studies indicate improved CT-derived bronchial parameters post-smoking cessation.
- Understanding the long-term effects of smoking cessation on airways is crucial for ex-smokers.
Purpose of the Study:
- To investigate the association between longer smoking cessation duration and bronchial parameters.
- To compare these associations in lung-healthy versus lung-unhealthy ex-smokers.
Main Methods:
- Cross-sectional analysis of low-dose CT scans from the ImaLife study (Lifelines cohort).
- Inclusion criteria: ex-smokers, ⩾45 years, ⩾10 pack-years, completed lung-function tests.
- Bronchial parameters (Pi10, wall thickness, luminal area, WAP) analyzed using multivariable linear regression (MLR).
Main Results:
- 1,869 ex-smokers included: 1,421 lung-healthy and 448 lung-unhealthy.
- In lung-unhealthy ex-smokers, longer cessation duration correlated with lower wall area percent (WAP) (-0.528% per 10 years, p=0.005).
- No significant associations were found in the lung-healthy group.
Conclusions:
- Longer smoking cessation duration is associated with decreased bronchial wall area percent in individuals with respiratory conditions.
- Findings suggest potential airway health benefits from sustained smoking cessation.
- Further longitudinal studies are recommended to confirm these observations.
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