Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

386
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
386
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
Lipid Digestion01:06

Lipid Digestion

90.6K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
90.6K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

315
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
315

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PfnsLTPd-5 interacts with PfGELP24 to enhance drought and salt stress tolerance in Paulownia fortunei.

BMC plant biology·2026
Same author

Rising threats of ceftolozane-tazobactam resistance in P. aeruginosa and A. baumannii: Species-, phenotype-, and geography-specific insights from a systematic review and meta-analysis.

Indian journal of medical microbiology·2026
Same author

Multiomics Integration Reveals AFB1 Causes Liver Damage Involving the Gut-Microbiota-Lipid Metabolism Axis in Piglet.

Journal of agricultural and food chemistry·2026
Same author

Long survival of PD-L1-positive mediastinal sarcomatoid carcinoma after immunotherapy and anti-angiogenic target therapy: A case report.

Oncology letters·2026
Same author

GPAT3 is associated with lipid deposition and AMPK signaling in skeletal muscle.

Biochemical and biophysical research communications·2026
Same author

Genome-wide transcriptional analysis of 14-3-3 genes in Paulownia fortunei under abiotic and biotic stresses.

BMC plant biology·2026

Related Experiment Video

Updated: Jun 4, 2025

Author Spotlight: Advancing Intestinal Bacteria Cultivation for Poultry
04:36

Author Spotlight: Advancing Intestinal Bacteria Cultivation for Poultry

Published on: May 10, 2024

680

Bile acids alleviate intestinal inflammation by modulating gut microbiota composition in LPS-challenged broilers.

Guoqiang Fan1, Wenjing Chen1, Jianxing He1

  • 1Key Laboratory of Animal Physiology & Biochemistry, Nanjing Agricultural University, Nanjing 210095, PR China.

Research in Veterinary Science
|January 4, 2025
PubMed
Summary

Dietary bile acids (BAs) and lithocholic acid (LCA) supplementation can prevent intestinal inflammation in broilers. These compounds improve gut health, regulate microbiota, and reduce inflammatory responses in challenged birds.

Keywords:
Bile acids compoundBroilerGut microbiotaIntestinal inflammationLithocholic acid

More Related Videos

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
08:53

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Published on: July 27, 2022

803
DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

47.2K

Related Experiment Videos

Last Updated: Jun 4, 2025

Author Spotlight: Advancing Intestinal Bacteria Cultivation for Poultry
04:36

Author Spotlight: Advancing Intestinal Bacteria Cultivation for Poultry

Published on: May 10, 2024

680
Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
08:53

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Published on: July 27, 2022

803
DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

47.2K

Area of Science:

  • Animal Science
  • Gastroenterology
  • Microbiology

Background:

  • Bile acids (BAs) are recognized as beneficial feed supplements in poultry.
  • Limited research exists on using BAs to prevent intestinal inflammation in broilers.
  • Lipopolysaccharide (LPS) challenge is a common model for inducing intestinal inflammation in broilers.

Purpose of the Study:

  • To investigate the effects of dietary BAs and lithocholic acid (LCA) on LPS-induced intestinal inflammation in broilers.
  • To evaluate the impact of BAs and LCA on gut morphology, inflammation markers, and bile acid metabolism.
  • To analyze the changes in gut microbiota composition following BAs and LCA supplementation.

Main Methods:

  • 180 Arbor Acres broilers were divided into four groups: control, LPS challenge, BAs + LPS, and LCA + LPS.
  • Dietary supplementation with BAs compound or LCA was administered.
  • LPS challenge was used to induce intestinal inflammation.
  • Measurements included liver mass, plasma AST, inflammatory cytokines, intestinal morphology, bile acid metabolism, and 16S rRNA gene sequencing for gut microbiota analysis.

Main Results:

  • LPS challenge significantly increased liver mass, plasma AST, and inflammatory cytokines.
  • BAs compound or LCA supplementation ameliorated intestinal damage, reduced inflammation, and improved bile acid metabolism.
  • Supplementation with BAs or LCA counteracted LPS-induced reductions in bacterial diversity and increased beneficial bacteria like Bacteroides and Bifidobacterium.
  • Increased abundance of Candidatus_Arthromitus correlated negatively with intestinal inflammatory cytokine levels.

Conclusions:

  • Dietary bile acids compound and lithocholic acid show potential in alleviating LPS-induced intestinal inflammation in broilers.
  • BAs and LCA supplementation can positively modulate gut microbiota composition and improve gut health.
  • These findings suggest BAs and LCA as promising feed additives for preventing intestinal inflammation in poultry.