Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

5.0K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.0K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

4.9K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
4.9K
Tumor Progression02:07

Tumor Progression

6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.2K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.2K
Skin Cancer01:30

Skin Cancer

3.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipid reprogramming of stratified squamous epithelium by the high-risk HPV E6 and E6/E7 oncoproteins.

Metabolomics : Official journal of the Metabolomic Society·2026
Same author

Estrogen receptor α (<i>Esr1</i>) mediates estrogen's ability to promote papillomavirus-induced cutaneous disease in male and female mice.

mBio·2026
Same author

Mutational signature-based classification uncovers emerging oral cancer subtypes with distinct molecular patterns.

International journal of oral science·2026
Same author

Clinicians' cancer risk assessment among patients with pulmonary nodules: a qualitative study.

Annals of the American Thoracic Society·2026
Same author

Integrated Single-Cell and Spatial Analysis Reveals Context-Dependent Myeloid-T Cell Interactions in Response to Immune Checkpoint Blockade in Head and Neck Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

<i>Mus musculus</i> papillomavirus MmuPV1 resists restriction by human APOBEC3B.

Journal of virology·2026
Same journal

Targeting EBV-associated gastric cancer by lytic induction therapy with nanatinostat.

Tumour virus research·2026
Same journal

Oncolytic virus hijacks GOT1 and pyrimidinosomes to fuel pyrimidine synthesis for replication in tumor cells.

Tumour virus research·2026
Same journal

Susceptibility of naturally human papillomavirus type 16 major capsid protein L1 variants to vaccines and predictions of future evolutionary trends.

Tumour virus research·2026
Same journal

PRMT5-mediated symmetric dimethylation of SHBs at Arg169 stabilizes SHBs and promotes angiogenesis and tumor growth.

Tumour virus research·2026
Same journal

30-hydroxygambogic acid activates overlapping and independent apoptotic pathways in HPV positive and HPV negative oral cancer cells.

Tumour virus research·2026
Same journal

HPV18E6 and CDK5 virus-host interaction is a prospective therapeutic target for HPV-positive cervical cancer.

Tumour virus research·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2025

Rapid in vivo Drug Response Prediction Using Leukemia Cell Grafts in Zebrafish Embryos
10:46

Rapid in vivo Drug Response Prediction Using Leukemia Cell Grafts in Zebrafish Embryos

Published on: May 23, 2025

159

Rapid-onset cancer.

Andrea Bilger1, Paul F Lambert1

  • 1McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI, 53705, USA.

Tumour Virus Research
|January 4, 2025
PubMed
Summary
This summary is machine-generated.

Some cancers develop slowly over decades, while rapid-onset cancers can form in months or even days. Viruses can accelerate cancer development by enabling cells to acquire malignant properties.

Keywords:
CancerCarcinogenesisCongenitalOnsetRapidSlowVirus

More Related Videos

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

718
A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
10:35

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

10.3K

Related Experiment Videos

Last Updated: Jun 4, 2025

Rapid in vivo Drug Response Prediction Using Leukemia Cell Grafts in Zebrafish Embryos
10:46

Rapid in vivo Drug Response Prediction Using Leukemia Cell Grafts in Zebrafish Embryos

Published on: May 23, 2025

159
Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

718
A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
10:35

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

10.3K

Area of Science:

  • Oncology
  • Virology
  • Cellular Biology

Background:

  • Human cancers typically progress slowly over decades, termed "slow-onset" cancers.
  • Conversely, "rapid-onset" cancers develop quickly, within months in humans or days in animal models.
  • Accelerated cancer development is often linked to factors like early development, immune deficiency, or viral infections.

Purpose of the Study:

  • To explore the mechanisms behind rapid-onset cancers.
  • To analyze rapid-onset cancers within the framework of the "hallmarks of cancer".
  • To investigate the specific role of viruses in inducing rapid-onset cancers.

Main Methods:

  • Literature review and conceptual analysis.
  • Discussion of cancer hallmarks.
  • Focus on viral oncogenesis.

Main Results:

  • Rapid-onset cancers can develop under specific conditions that promote malignancy.
  • Viruses possess mechanisms that can expedite the acquisition of cancer-driving cellular properties.
  • Viral infections are potent triggers for rapid malignant transformation.

Conclusions:

  • Viruses are particularly adept at inducing rapid-onset cancers.
  • Understanding viral mechanisms is key to combating aggressive cancer forms.
  • The "hallmarks of cancer" provide a useful framework for studying rapid oncogenesis.