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Related Experiment Video

Updated: May 7, 2025

Model of Ischemia and Reperfusion Injury in Rabbits
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Amniotic Fluid as a Potential Treatment for Vocal Fold Scar in a Rabbit Model.

Jenny L Pierce1, Brendan Olson2, Ray M Merrill3

  • 1Department of Otolaryngology - Head and Neck Surgery, University of Utah, Salt Lake City, UT.

Journal of Voice : Official Journal of the Voice Foundation
|January 4, 2025
PubMed
Summary

Human amniotic fluid (AF) shows promise for vocal fold (VF) healing by reducing inflammation and improving tissue properties over time. This pilot study suggests AF may be a superior treatment for VF injury compared to hyaluronic acid (HA) and saline (SA).

Keywords:
Vocal fold scar—Amniotic fluid—Hyaluronic acid—Rabbit

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Area of Science:

  • Regenerative Medicine
  • Otolaryngology
  • Biomaterials Science

Background:

  • Vocal fold (VF) injury can lead to scarring, a challenging condition to treat.
  • Human amniotic fluid (AF) is being investigated for its potential in tissue repair and regeneration.

Purpose of the Study:

  • To evaluate the efficacy of human amniotic fluid (AF) in vocal fold (VF) wound healing.
  • To compare the wound healing properties of AF with hyaluronic acid (HA) and saline (SA) in a rabbit model.

Main Methods:

  • A randomized, controlled pilot study involving 60 New Zealand white rabbits.
  • Unilateral VF biopsy with immediate treatment of AF, HA, or SA.
  • Assessment of VF viscoelastic properties (rheology) and inflammation (RT-qPCR) at 4 and 10 weeks post-injury.

Main Results:

  • AF treatment demonstrated improved VF viscoelastic properties at 10 weeks compared to SA and HA.
  • AF and HA initially increased inflammatory cytokines compared to SA, but AF showed reduced inflammation at 10 weeks.
  • AF was the only group with significant inflammation reduction from 4 to 10 weeks.

Conclusions:

  • Human amniotic fluid (AF) exhibits wound healing effects in VF injuries by reducing inflammation and enhancing viscoelasticity over time.
  • AF demonstrated superior outcomes compared to HA and SA in this rabbit model.
  • Further research is warranted to explore AF for human VF wound healing.