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Updated: May 7, 2025

Nanomanipulation of Single RNA Molecules by Optical Tweezers
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Spontaneous base flipping helps drive Nsp15's preferences in double stranded RNA substrates.

Zoe M Wright1, Kevin John Butay2,3, Juno M Krahn2

  • 1Molecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA. zoe.wright@nih.gov.

Nature Communications
|January 4, 2025
PubMed
Summary

Coronaviruses use Nsp15 endoribonuclease to evade immune detection by cleaving viral RNA. This study shows Nsp15 preferentially cleaves accessible, unpaired uridines, aiding viral immune evasion strategies.

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