Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hearing01:31

Hearing

51.1K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
51.1K
Pleiotropy01:33

Pleiotropy

37.5K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
37.5K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.0K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.0K
Autoimmune Disorders01:29

Autoimmune Disorders

313
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
313
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

8.3K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
8.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetically Predicted Associations of CX3CL1 and UMOD with Acute Kidney Injury Risk: Evidence from Mendelian Randomization and Clinical Validation.

Journal of inflammation research·2026
Same author

Shared and culture-specific brain networks for emotional facial discrimination: Evidence from predictive modeling.

Neuropsychologia·2026
Same author

A self-perpetuating neuron-intrinsic GSDMD-mtDNA-AIM2 inflammasome axis drives neuronal pyroptosis and cognitive impairment after traumatic brain injury.

Frontiers in immunology·2026
Same author

The timing of visual selective attention in fronto-parietal network: TMS behavioral and brain structural evidence.

Neuroscience·2026
Same author

The role of inferior frontal gyrus in emotion regulation: Evidence from fMRI and tDCS investigation.

International journal of psychophysiology : official journal of the International Organization of Psychophysiology·2026
Same author

Modeling and Simulation of Mass Transfer in Food Processing: Recent Advances in Governing Equations, Workflow, and Applications.

Foods (Basel, Switzerland)·2026

Related Experiment Video

Updated: May 7, 2025

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

19.1K

Causal relationship between psoriasis and sudden deafness: a Mendelian randomization study.

Linrong Wu1, Yiming Shen2, Junjun Zhang3

  • 1Department of Otolaryngology, Head and Neck Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, 315100, China.

Archives of Dermatological Research
|January 4, 2025
PubMed
Summary

Genetic analysis reveals a causal link between psoriasis and sudden sensorineural hearing loss (SSNHL). Individuals with psoriasis face an increased risk of developing SSNHL, underscoring a significant health connection.

Keywords:
Mendelian randomizationPsoriasisSingle nucleotide polymorphismSudden deafness

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K
Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
07:13

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

2.1K

Related Experiment Videos

Last Updated: May 7, 2025

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

19.1K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K
Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
07:13

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

2.1K

Area of Science:

  • Genetics
  • Otolaryngology
  • Dermatology

Background:

  • Psoriasis is a chronic autoimmune disease.
  • Sudden sensorineural hearing loss (SSNHL) is an idiopathic condition.
  • The genetic relationship between psoriasis and SSNHL remains unclear.

Purpose of the Study:

  • To investigate the potential genetic link between psoriasis and SSNHL.
  • To determine if genetic factors predispose individuals to both conditions.

Main Methods:

  • Utilized genome-wide association study (GWAS) data from the IEU OpenGWAS project.
  • Employed Mendelian randomization (MR) analysis, specifically the inverse variance weighted (IVW) method.
  • Conducted sensitivity analyses including MR-Egger and Leave-one-out to ensure robustness and rule out pleiotropy.

Main Results:

  • Mendelian randomization analysis indicated a significant causal relationship between psoriasis and SSNHL (OR=808.86, P=0.02).
  • Sensitivity analyses confirmed the robustness of the causal effect, with no significant heterogeneity or horizontal pleiotropy detected.
  • The results suggest a reliable genetic association, free from confounding factors.

Conclusions:

  • There is a genetically determined causal relationship between psoriasis and an elevated risk of SSNHL.
  • This finding highlights a shared genetic susceptibility between the two conditions.
  • Further research may explore underlying biological mechanisms connecting psoriasis and hearing loss.