Related Experiment Video
Updated: May 7, 2025
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
The GLOB-cAGE consortium: a global cardiovascular collaborative network of older adults with cardiovascular disease
Jie Jun Wong1, Gary Tse2, Huyen Thi Thanh Vu3,4
1Department of Cardiology, National Heart Centre Singapore, Singapore 169609, Singapore.
Insights
The Global Cardiovascular Aging Research Consortium (GLOB-cAGE) unites global cohorts of older adults with cardiovascular disease. This initiative harmonizes data for advanced meta-regression analyses, improving research representation and addressing evidence gaps.
Area of Science:
- Gerontology
- Cardiovascular Epidemiology
- Global Health
Background:
- The Global Cardiovascular Aging Research Consortium (GLOB-cAGE) is a new international initiative.
- It unites longitudinal cohorts of older individuals with cardiovascular disease (CVD) worldwide.
- Aims to harmonize data for meta-regression analyses on CVD in aging populations.
Purpose of the Study:
- To establish a global data repository for cardiovascular research in older adults.
- To perform meta-regression analyses using standardized subject-level data.
- To enhance the representation of diverse global populations in aging and CVD research.
Main Methods:
- Involves population-based longitudinal cohort studies and clinical trials.
- Includes individuals diagnosed with CVD and those at risk for primary prevention.
- Requires a minimum sample size of 100 participants (age >65 or >40 with long-term follow-up).
Main Results:
- Currently includes 27 studies from 9 countries with 10 participating teams.
- Facilitates collaboration through data sharing (anonymized or raw data).
- Offers alternative participation methods for sites unable to share data.
Conclusions:
- GLOB-cAGE addresses evidence gaps due to underrepresentation of older adults in clinical trials.
- Promotes high-quality epidemiological studies on cardiovascular health in aging populations.
- Enhances global collaboration and data standardization in geriatric cardiovascular research.
Abstract:
The Global Cardiovascular Collaborative Network of Older Adults with Cardiovascular Disease (GLOB-cAGE) is a newly established, unprecedented consortium that brings together cohorts of older individuals with cardiovascular disease (CVD) worldwide. The GLOB-cAGE aims to harmonize nonidentifiable data from longitudinal cohorts examining cardiovascular health and CVD diagnosis and management in older individuals to perform meta-regression analyses using combined repositories of standardized subject-level data points. Studies registered into GLOB-cAGE are population-based longitudinal cohort studies or clinical trials, either ongoing or completed, that involve assessing cardiovascular health as a central objective. Cross-sectional studies that significantly contribute to cardiovascular research in older individuals may also be included. The GLOB-cAGE will consist of individuals already diagnosed with CVD and primary prevention of individuals at different risks of CVD. The studies should have a minimum sample size of 100 participants, and the participants are either adults older than 65 years or older than 40 years with longitudinal follow-up over the next few decades. Enrollment in GLOB-cAGE may involve collaboration on nonidentifiable or anonymized raw or processed data for joint analyses. Sites unable to provide raw or processed data due to institutional or other reasons may participate in alternative ways, including performing separate analyses in-house. At the time of writing, there are at least 10 participating teams from 9 countries and 27 studies enrolled in GLOB-cAGE. The GLOB-cAGE consortium is an international effort to bring together CVD research in older individuals, focusing on providing greater representation from diverse countries battling population aging. It addresses the evidence gaps from the insufficient enrolment of older individuals in randomized controlled trials and permits investigators to conduct high-quality epidemiologic studies. This article is part of a Special Collection on Cross-National Gerontology.
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