Related Experiment Video

Updated: Jun 4, 2025

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
13:18

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

1.2K

Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020

Yanqing Liu1, Jie Chen2, Xiang Li2

  • 1Department of Pharmacy, the Thirteenth People's Hospital of Chongqing, Chongqing Geriatrics Hospital, Chongqing 400053, China.

Pharmacological Research
|January 5, 2025
PubMed

Insights

Natural products offer promising avenues for developing novel RAS-targeted cancer therapies. This review explores their mechanisms, challenges, and strategies for clinical success.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Chemistry

Background:

  • RAS proteins are crucial in cancer signaling, frequently mutated and hyperactivated.
  • Targeting RAS remains challenging despite extensive research on inhibitors.
  • Natural products represent a rich source for novel therapeutic drug discovery.

Purpose of the Study:

  • To review recent advancements in targeting RAS-mutated cancers with natural products.
  • To categorize natural products by their mechanisms of action against RAS.
  • To discuss clinical translation challenges and potential solutions for natural product-based therapies.

Main Methods:

  • Literature review of natural products targeting RAS.
  • Categorization of natural products based on their molecular mechanisms.
  • Analysis of pharmacokinetic challenges and clinical translation strategies.

Main Results:

  • Identified diverse natural products with potential anti-RAS activity.
  • Classified natural products by their specific mechanisms against RAS signaling pathways.
  • Highlighted pharmacokinetic limitations and potential for overcoming them.

Conclusions:

  • Natural products show significant promise as a source for novel RAS-targeted cancer drugs.
  • Combination therapy, structural optimization, and advanced drug delivery can enhance efficacy.
  • Further research is needed to overcome clinical translation hurdles for these agents.
Keywords:
CancerNatural productsRASTargeted therapy

More Related Videos

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.5K
Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer07:13

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

Published on: March 26, 2014

23.3K

Related Concept Videos

The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
6.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K
Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
3.9K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.2K