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A Straightforward Synthesis of Pinocembrin
Kento Iwai1,2,3, Nagatoshi Nishiwaki1,2
1School of Engineering Science, Kochi University of Technology.
Abstract:
A simple synthetic method for pinocembrin from cinnamic acid and 1,3,5-trihydroxybenzene was provided. This method can be performed in one-pot two steps reaction using inexpensive chemical reagents, whereas conventional methods need multiple steps from somewhat expensive starting reagents. The experimental procedure is facilitated, that is, to a DMF solution of cinnamoyl chloride generated in situ, a solution of 1,3,5-trihydroxybenzene and AlCl 3 in DCE/PhNO 2 was added, and the resultant mixture was heated to afford pinocembrin. This method does not require protection of phenolic hydroxy groups.
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